Microsoft Excel 不能访问文件"C:\Users\iImax\Documents\test.xls"。 可能的原因有以下几个:

• 文件名称或路径不存在。

• 文件正被其他程序使用。

• 您正要保存的工作簿与当前打开的工作簿同名。

用Quartz.Net写了个服务，实现将office文档转PDF功能。发布到Windows Server 2008 出现上述错误。

google之：

Windows 2008 Server x64

Please make this folder.

C:/Windows/SysWOW64/config/systemprofile/Desktop

Windows 2008 Server x86

Please make this folder.

C:/Windows/System32/config/systemprofile/Desktop

...instead of dcomcnfg.exe.

This operation took away office automation problems in my system.

A Desktop folder seems to be necessary in the systemprofile folder to open file by Excel.

It disappears from Windows2008, Windows2003 had the folder,
and I think it cause this error.

即在C:/Windows/System32/config/systemprofile和C:/Windows/SysWOW64/config/systemprofile目录下创建名为Desktop目录即可解决问题